Project B10

Magnetoelectric Sensor Systems for Cardiologic Applications

Current standard electrocardiography is a useful and easily applicable method that has been in clinical use for more than hundred years. However, it is hampered by low spatial resolution. Thus, precise electro-anatomical mapping of arrhythmias still has to be conducted by invasive catheterization. The main long-term objective of this project is to answer the question whether invasive mapping of arrhythmic substrates (current standard) can be replaced by a non-invasive alternative, namely analyses using signals obtained from ME sensors combined with electric measurements.

We will thus investigate if a multi-channel combined ECG/MCG (electrocardiogram/magnetocardiogram) approach allows for reliable non-invasive localization of the origin of cardiac arrhythmias. This is becoming even more important, as recently stereotactic body radiation therapy was successfully applied for ablation of ventricular tachycardia, promising a completely non-invasive way to cure arrhythmias in the future.

To perform the required measurements with a multitude of magnetic (both ME sensors originating from this CRC and already established systems) as well as electric sensors, individual real-time signalto-noise ratio estimations of all involved sensors will be investigated that permit optimal sensor placement, sensor signal combination, and parameter extraction. An appropriate automatic signal quality analysis should guarantee a minimum recording time for patients. To answer these research questions, forward modelling and a solution of the inverse problem is necessary. Here the results of the former CRC project B3 will be used and further extended. To evaluate the accuracy and clinical utility of this approach, we plan to compare it with results from electrophysiological studies (current standard) in 3 different groups of patients:

  • premature ventricular contractions,
  • idiopathic ventricular tachycardia,
  • ischemic ventricular tachycardia.

For each patient, magnetic resonance imaging (MRI) and computed tomography (CT) for anatomy and electric and magnetic measurements will be performed.

 

Gerhard Schmidt
Prof. Dr.-Ing.
Lead of projects B2, B9, B10, and Z2
Norbert Frey
Prof. Dr. med.
Lead of project B10
Erik Engelhardt
M.Sc.
Doctoral researcher

 

Role within the Collaborative Research Centre

Z1: This project is closely interlinked with the ME sensor projects, especially those that allow for low frequency (5 to 30 Hz) measurements
A8: The sensor models that are investigated in A8, will be incorporated in the forward modelling. A first sensor model version available in 2021 will be replaced with extended versions in 2023.
B1, Z2: B10 will benefit from B1 adapting system front-ends and small sensor arrays to the requirements of B10. In turn, we will communicate test results back to B1 to facilitate the development of suit- able measurement systems after transfer of mature sub-systems to Z2.
B2, B9: The project will use the same real-time framework as B2 and B9. Thus, all extensions made in either one of the projects will benefit the other and immediately speed up development.
B9,T1: All study participant management and data acquisition procedures will be shared with B9 and T1.

 

Project-related Publications

J. Reermann, E. Elzenheimer, G. Schmidt, Real-time Biomagnetic Signal Processing for Uncooled Magnetometers in Cardiology. IEEE Sensors Journal, Volume 15, Number 10, Pages 4237-4249 (2019). DOI: 10.1109/JSEN.2019.2893236

Contact

sfb1261@tf.uni-kiel.de

Chairman:

Prof. Dr. Eckhard Quandt

Kiel University
Institute for Materials Science

 

Internal server

 

CAU

Christian-Albrechts-Universität zu Kiel (CAU)

Christ.-Albrechts-Platz 4
D-24118 Kiel

UKSH

University Hospital Schleswig-Holstein, Campus Kiel (UKSH)

Arnold-Heller-Straße 3
D-24105 Kiel

ISIT

Fraunhofer Institute for Silicon Technology, Itzehoe (ISIT)

Fraunhoferstrasse 1
D-25524 Itzehoe  

IPN

IPN - Leibniz-Institut für die Pädagogik der Naturwissenschaften und Mathematik 

Olshausenstraße 62 
D-24118 Kiel

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