Project B6

Multimodal Mapping of Nerve Pathology with Magnetoelectric Sensors

The objective of project B6 is the non-invasive mapping of nerve function and dysfunction (pathology) by a combination of magnetoelectric (ME) sensor sampling with ultrasound or magnetic resonance (MR) imaging. In step 1, we will establish the experimental set-up with the measurement and analysis pipeline using a phantom. In step 2, we will adapt these to in vivo conditions (healthy human nerve). Finally, in step 3, we will examine patient cohorts with different types of nerve pathology and assess added value of the novel multimodal nerve mapping in comparison to established electrical nerve conduction studies.

Role within the Collaborative Research Centre

Close cooperation is planned with the following partners:

Z1, A3:	This project is closely interlinked with the ME sensor projects, especially those that operate in resonance and those where the resonance frequency can be adjusted.
B1:	B6 will benefit from B1adapting system front-ends and small sensor arrays to the requirements of B6. In turn, we will communicate test results back to B1 to facilitate the development of suitable measurement systems after transfer of mature sub-systems to Z2.
B2, B6:	The project will use the same real-time framework as projects B2 and B6. Thus, all extensions made in either one of the projects will benefit the other and immediately speed up development.
B3:	We will share data with project B3 for the advancement of inverse solution techniques.
B5:	All patient management and data acquisition will be shared with project B5, via which a neurophysiologist/technician will be employed. Patients will be recruited from the same site (Department of Neurology, UKSH Kiel).
Z2:	We will share work with the other projects that are producing or extending phantoms.

Project B6 will participate in the focus group F3 “Biomagnetic Signal Analysis”.

Project-related Publications

E. Elzenheimer, H. Laufs, W. Schulte-Mattler, G. Schmidt, Magnetic Measurement of Electrically Evoked Muscle Responses with Optically Pumped Magnetometers. IEEE Transactions on Neural Systems and Rehabilitation Engineering : a publication of the IEEE Engineering in Medicine and Biology Society, early access (2020), doi: 10.1109/TNSRE.2020.2968148

E. Elzenheimer, H. Laufs, W. Schulte-Mattler, G. Schmidt, Signal Modeling and Simulation of Temporal Dispersion and Conduction Block in Motor Nerves. IEEE Transactions on Biomedical Engineering, early access (2019). https://doi.org/10.1109/TBME.2019.2954592

J. Reermann, E. Elzenheimer, G. Schmidt, Real-time Biomagnetic Signal Processing for Uncooled Magnetometers in Cardiology. IEEE Sensors Journal, Volume 15, Number 10, Pages 4237-4249 (2019). DOI: 10.1109/JSEN.2019.2893236

E. Elzenheimer, F. Weitkamp, H. Laufs, T. Sander-Thömmes, G. Schmidt, Magnetoneurografie eines elektrisch stimulierten Armnervs. Biosignale Workshop, Erfurt, Germany (2018).

F. Weitkamp, E. Elzenheimer, W. Schulte-Mattler, G. Schmidt, H. Laufs, Multimodal Mapping of Nerve Pathology with a Multichannel Approach. DGKN, Berlin, Germany (2018). https://doi.org/10.1016/j.clinph.2018.04.657

C. Bald, E. Elzenheimer, J. Reermann, T. Sander-Thömmes, G. Schmidt, Amplitudenverlauf des Herzmagnetfeldes als Funktion des Abstandes. Biosignale Workshop, Erfurt, Germany (2018).

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Project B6

Multimodal Mapping of Nerve Pathology with Magnetoelectric Sensors

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Role within the Collaborative Research Centre

Project-related Publications

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